Yakuza Past, Present and Future: The Changing Face of Japan\u27s Organized Crime Syndicates

While Japanese crime syndicates are deeply entrenched in the history and culture of Japan, much of what is known in the Western world about the Yakuza is primarily the result of stereotyping generated by media-driven sensationalism and lowbudget motion pictures. Judgment on the crime syndicates\u27 continued existence, modes of operation, and relatively high visibility in Japan is oftentimes passed based on socio-cultural perceptions of deviance that differ from those in Japanese culture. Taking the form of a book review essay, this paper aims to re-introduce the reader to Japan\u27s crime syndicates with the goal of replacing stereotypes and myths with factual information. Utilizing two seminal works written by authorities of the field, the paper chronicles the history of the Yakuza\u27s origins and evolution, outlines their organizational structures, describes the groups\u27 past and current operations, and provides a brief overview of the crime syndicates\u27 likely future

Digital Repositories and Open Access: Information Without Limits

For many libraries, the Digital Repository has become the main storage center for materials created by the community they serve. Such materials can include important historical records, local newspapers, community newsletters, as well as articles, presentations, data sets, images, videos and other multimedia items. In this way, the repository takes on a central role in placing free, open access materials into the hands of the public. While many repositories are currently managed by universities, their benefits reach beyond the walls of academia to include K-12 students as well as the public at large. Thus, all librarians are encouraged to utilize the materials housed in repositories during their educational programming. Doing so has the advantage of providing reliable information at no cost to their patrons while at the same time creating ties between the university and the local community. Furthermore, the use of open access materials during instruction sessions and reference interactions presents the librarian with many opportunities to discuss the increased importance of fair use and intellectual property issues

Access to Digital Libraries for Disadvantaged Users

Digital libraries, designed to serve people and their information needs in the same way as traditional libraries, present distinct advantages over brick and mortar facilities: elimination of physical boundaries, round-the-clock access to information, multiple access points, networking abilities, and extended search functions. As a result, they should be especially well-suited for the disadvantaged. However, minorities, those affected by lower income and education status, persons living in rural areas, the physically disabled, and developing countries as a whole consistently suffer from a lack of accessibility to digital libraries. This paper evaluates the effectiveness and relevance of digital libraries currently in place and discusses what could and should be done to improve accessibility to digital libraries for the disadvantaged

Access to Digital Libraries for Disadvantaged Users

Digital libraries, designed to serve people and their information needs in the same way as traditional libraries, present distinct advantages over brick and mortar facilities: elimination of physical boundaries, round-the-clock access to information, multiple access points, networking abilities, and extended search functions. As a result, they should be especially well-suited for the disadvantaged. However, minorities, those affected by lower income and education status, persons living in rural areas, the physically disabled, and developing countries as a whole consistently suffer from a lack of accessibility to digital libraries. This paper evaluates the effectiveness and relevance of digital libraries currently in place and discusses what could and should be done to improve accessibility to digital libraries for the disadvantaged

Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency

AbstractExtremely low concentrations of high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo) AI are features of Tangier disease caused by autosomal recessive mutations in ATP-binding cassette transporter A1 (ABCA1). Less deleterious, but dominantly inherited mutations cause HDL deficiency. We investigated causes of severe HDL deficiency in a 42-year-old female with progressive coronary disease.ApoAI-mediated efflux of cholesterol from the proband's fibroblasts was less than 10% of normal and nucleotide sequencing revealed inheritance of two novel mutations in ABCAI, V1704D and L1379F. ABCA1 mRNA was approximately 3-fold higher in the proband's cells than in control cells; preincubation with cholesterol increased it 5-fold in control and 8-fold in the proband's cells, but similar amounts of ABCA1 protein were present in control and mutant cells. When transiently transfected into HEK293 cells, confocal microscopy revealed that both mutant proteins were retained in the endoplasmic reticulum, while wild-type ABCA1 was located at the plasma membrane.Severe HDL deficiency in the proband was caused by two novel autosomal recessive mutations in ABCA1, one (V1704D) predicted to lie in a transmembrane segment and the other (L1379F) in a large extracellular loop. Both mutations prevent normal trafficking of ABCA1, thereby explaining their inability to mediate apoA1-dependent lipid efflux

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by <i>in vitro</i> cellular studies

P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and posing a threat for the therapeutic treatment of several diseases, including cancer and central nervous disorders. Herein, a virtual screening campaign followed by experimental validation in Caco-2, MDKCII, and MDKCII mdr1 transfected cell lines has been conducted for the identification of novel phospholipids with P-gp transportation inhibitory activity. Phosphatidylinositol-(1,2-dioctanoyl)-sodium salt (8∶0 PI) was found to significantly inhibit transmembrane P-gp transportation in vitro in a reproducible-, cell line-, and substrate-independent manner. Further tests are needed to determine whether this and other phosphatidylinositols could be co-administered with oral drugs to successfully increase their bioavailability. Moreover, as phosphatidylinositols and phosphoinositides are present in the human diet and are known to play an important role in signal transduction and cell motility, our finding could be of substantial interest for nutrition science as well

Maternal outcomes and risk factors for COVID-19 severity among pregnant women.

Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease

Rapid and highly variable warming of lake surface waters around the globe

In this first worldwide synthesis of in situ and satellite-derived lake data, we find that lake summer surface water temperatures rose rapidly (global mean = 0.34°C decade-1) between 1985 and 2009. Our analyses show that surface water warming rates are dependent on combinations of climate and local characteristics, rather than just lake location, leading to the counterintuitive result that regional consistency in lake warming is the exception, rather than the rule. The most rapidly warming lakes are widely geographically distributed, and their warming is associated with interactions among different climatic factors - from seasonally ice-covered lakes in areas where temperature and solar radiation are increasing while cloud cover is diminishing (0.72°C decade-1) to ice-free lakes experiencing increases in air temperature and solar radiation (0.53°C decade-1). The pervasive and rapid warming observed here signals the urgent need to incorporate climate impacts into vulnerability assessments and adaptation efforts for lakes

Theft and Vandalism of Books, Manuscripts, and Related Materials in Public and Academic Libraries, Archives, and Special Collections

While book theft and vandalism in public and academic libraries, as well as archives and special collections, are not considered a modern problem, they have, in recent years, become a matter of increasing concern to these institutions. Easy access to materials housed in multi-story libraries difficult to effectively supervise; the online presence of archives and special collections detailing the contents of their collections to attract researchers and visitors; and a seemingly growing number of persons willing to express their personal convictions and beliefs by removing or destroying items from public and private collections, are among the primary reasons for the ongoing loss of materials. This research paper examines the motives behind book theft and vandalism, summarizes existing security measures, and offers suggestions for theft and vandalism prevention